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Lorazepam's sedative/hypnotic effects, and the duration of clinical effects from a single dose, make it an appropriate choice for the short term treatment of insomnia, particularly in the presence of severe anxiety. Lorazepam has relatively potent anxiolytic effects and its best known indication is the short-term management of severe anxiety. 4 Contraindications and special considerations.One study concluded that, compared to other benzodiazepines, lorazepam has relatively high addictive potential. Since its introduction in 1971, lorazepam's principal use has been in treating the symptom of anxiety. It is a unique benzodiazepine insofar as it has also found use as an adjunct antiemetic in chemotherapy. It has all five intrinsic benzodiazepine effects: anxiolytic, sedative/hypnotic, amnesic, anticonvulsant and muscle relaxant, to different extents. Lorazepam (also known by its brand name Ativan) is a benzodiazepine tranquilizer with short to medium duration of action. For example, consuming alcohol can reduce clearance speed by 18%.9-chloro-6-(2-chlorophenyl)-4-hydroxy- 2,5-diazabicycloundeca- 5,8,10,12-tetraen-3-one The use of other medications, illicit drugs, or alcohol, in combination with Ativan, can influence its absorption, metabolism, and rate of clearance from a person’s system. Frequent and/or long-term users of Ativan are more likely to develop a tolerance to the drug’s effects and, as a result, continue to increase their dosage. Frequency and Duration of UseĪ person who takes several doses of Ativan each day will take longer to eliminate the drug than say, others who only use it once per day. Metabolic RateĪs with all substances, people with a relatively rapid metabolic rate will likely process and eliminate Ativan faster than those with slower rates. What’s more, renal issues could impede the excretion of Ativan from the body. Studies have shown that, while liver impairment does not appear to have a significant effect on the body’s ability to eliminate Ativan, kidney function could, in fact, impact how rapidly the drug is cleared. Genetic factors such as the presence of liver enzymes and kidney function can both play a role in how the body breaks down Ativan. People who do not metabolize Ativan well may take longer to expel it from their system. There is some evidence that being overweight can actually accelerate Ativan clearance, while a shorter or lighter person may take longer to eliminate the drug than a taller or heavier person who has used the same amount. Body Height and WeightĪ person’s height and weight relative to the dosage of Ativan may impact how long it remains in the system. Theories as to why younger people eliminate Ativan more efficiently than older people include co-existing health conditions, blood flow, metabolic rate, and organ functionality. Older adults, on average, may exhibit a 22% slower clearance rate of Ativan when compared to younger individuals. Individual factors can influence how long Ativan remains in a person’s system and how rapidly it is eliminated.
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Factors that Affect How Long Ativan Stays in the System